Stop Creating So Many Free Radicals in Your Colon

Colon cancer risk in Westernized populations may be reduced by reducing animal product consumption and thereby reducing  “aggressive” elements corresponding to animal protein and fat. I’ve explored how animal protein can putrefy and produce the rotten egg fuel that could be poisonous to DNA (see Putrefying Protein and “Toxifying” Enzymes), however what concerning the fats? It can stimulate the synthesis and secretion of bile acids into the intestine.

Bile helps the physique digest fats. So, extra fat in the intestines means extra bile in the intestines, which wouldn’t be an issue besides bile acids, especially secondary bile acids, have lengthy been suspected as being carcinogenic. Bile acids stimulate the growth of micro organism, which convert the primary bile acids our livers make into secondary bile acids. And, secondary bile acids have been proven to be cancer-causing.

As described in my How to Reduce Carcinogenic Bile Acid Production video, this could help explain why fat-rich diets are correlated with colon most cancers. High saturated fats consumption is related to elevated levels of bile, which is what you are likely to see in individuals with colon most cancers. As such, they are thought-about tumor-producing elements in colorectal cancer improvement and maybe additionally breast most cancers, as these secondary bile acids can get absorbed into the blood stream and flow into all through the physique. (See Breast Cancer and Constipation for extra on this.)

This might assist explain the terribly low charges of colon cancer in sub-Saharan Africa, with native Africans putting out just a fraction of the secondary bile acids of African Americans. Well, if a weight-reduction plan excessive in animal fats stimulates the expansion of those toxic and carcinogenic secondary bile salt-producing micro organism, what about diets that don’t embrace any animal fats? We’ve recognized for greater than 40 years that these eating plant-based diets have much less bile in their stools and a decreased capacity to create colon carcinogens. Those eating vegetarian produce just a fraction of a few of the secondary bile acids implicated in most cancers—about 70% less. Within just one week on a plant-based weight-reduction plan, the bacterial enzyme exercise to produce these secondary bile acids is minimize in half. Within a month, their presence is reduce in half, as nicely.

One of an important poisonous effects of those bile acids—the BAs in our BMs—is the elevated manufacturing of free radicals. That’s one of many methods they will injury our DNA and undermine our DNA repair pathways.

Hydroxyl radicals are some of the damaging free radicals, which may improve colon cancer danger. They solely final a few billionth of a second however, in that point, can convert harmless substances in the bowel to DNA-damaging, mutagenic substances, and bile acids are believed to promote this process. But, in the event you switch individuals to a vegetarian eating regimen for less than 12 days, you will get a 13-fold drop in hydroxyl free radical production.

So, fecal free radicals might activate carcinogens in the colon. On an ordinary American weight loss plan, the quantity of free radicals produced in the stool is sort of exceptional, akin to that which might be produced by a fatal dose of gamma radiation. So, what can we do about it? What’s an achievable, sensible measure to decrease free radical formation in our colon? We might try and “colonize the colons of high risk patients with genetically engineered, antioxidant-producing bacteria,” but why not just eat a extra plant-based eating regimen?

What about fiber? See Fiber vs. Breast Cancer for extra info on why fiber may be so protecting.

You can discover more on the microbiome in Stool pH and Colon Cancer, Preventing Ulcerative Colitis with Diet, and Why Do Plant-Based Diets Help Rheumatoid Arthritis?.

In health,

Michael Greger, M.D.

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